PDF Chagas Disease: Part A: 75 (Advances in Parasitology)

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Chat with us in Facebook Messenger. Find out what's happening in the world as it unfolds. More Videos Story highlights In most cases, Chagas symptoms are absent or mild and unspecific A new study has found that infection more than doubles a person's risk of death. Their name stems from the fact that they like biting humans around their lips and faces as they sleep, after which they defecate into the wound with feces that harbor an infectious parasite, Trypanasoma cruzi.

The parasite then enters the bloodstream and causes Chagas disease, also known as trypanosomiasis. Though the disease is generally considered to be mild or even asymptomatic among most, a new study has found that deaths fueled by the infection are much more common than we know -- and are going unrecognized.

Could one discovery take on three deadly parasites? Ligia Capuani, an infectious disease researcher at Faculdade de Medicina da Universidade de Sao Paulo, in Brazil, who led the research. Diagnosis is a challenge in many parts of Central and South America, where the disease is most prevalent, with people often finding out that they are infected only when they donate blood, explained Capuani. The kissing bugs behind the disease have also been reported in 25 US states, with the largest concentration in the South. The research team analyzed data from more than 8, people who donated blood between and and compared mortality among people who tested positive and negative for infection with T.

Product description Review "One is struck by the quality and scholarship of the various chapters and the obviously efficient editing. Louis M. Weiss M. Weiss received his M. H degrees from the Johns Hopkins University in Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine.

Health Econ. Dumas, C. Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. EMBO J. El-Sayed, N. The genome sequence of Trypanosoma cruzi , etiologic agent of Chagas disease. Science , — Faundez, M. Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.

Agents Chemother. Field, M. Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need. Filardi, L. Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Francisco, A. Biological factors that impinge on Chagas disease drug development. Parasitology , — Garami, A.

Disruption of mannose activation in Leishmania mexicana : GDP-mannose pyrophosphorylase is required for virulence, but not for viability. Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants. A differential role for actin during the life cycle of Trypanosoma brucei. Gibellini, F. Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei : the ethanolamine and choline kinases.

The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei. Giorgi, M. Trans-sialidase and mucins of Trypanosoma cruzi : an important interplay for the parasite. Guedes-da-Silva, F. GPI-anchored proteins and free GPI glycolipids of procyclic form Trypanosoma brucei are non-essential for growth, are required for colonization of the tsetse fly, and are not the only components of the surface coat.

Cell 17, — Haubrich, B. Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth.

Lipid Res. Hilley, J. Leishmania mexicana mutants lacking glycosylphosphatidylinositol GPI :protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins. Cell 11, — Hoekstra, W. Clinical candidate VT's antiparasitic effect in vitro , activity in a murine model of chagas disease, and structural characterization in complex with the target enzyme CYP51 from Trypanosoma cruzi.

Hong, Y. Trypanosome glycosylphosphatidylinositol biosynthesis. Korean J. FEBS Lett. Hudock, M. Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.


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Iyer, J. Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response, and virulence. Jones, N. Genetically Validated drug targets in leishmania : current knowledge and future prospects. ACS Infect. Kangussu-Marcolino, M. Conditional removal of selectable markers in Trypanosoma cruzi using a site-specific recombination tool: proof of concept. Kawasaki, Y. Finding a better path to drug selectivity.

Today 16, — Kleczka, B. Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence. Kolev, N. RNA interference in protozoan parasites: achievements and challenges. Cell 10, — Krauth-Siegel, R. Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.

Acta , — Krieger, S. Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress. Lander, N. Lepesheva, G. Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi. VFV as a new effective CYP51 structure-derived drug candidate for chagas disease and visceral leishmaniasis.

Li, Y. Transcriptome remodeling in Trypanosoma cruzi and human cells during intracellular infection. Liendo, A. Sterol composition and biosynthesis in Trypanosoma cruzi amastigotes. Lillico, S. Cell 14, — Ma, Y. Inducible suicide vector systems for Trypanosoma cruzi. Microbes Infect. MacRae, J. The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology. TDR Targets: a chemogenomics resource for neglected diseases. Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.

McCall, L. Targeting Ergosterol biosynthesis in Leishmania donovani : essentiality of sterol 14 alpha-demethylase. Morillo, C. Benznidazole and posaconazole in eliminating parasites in asymptomatic T. Moutiez, M. Purification and characterization of a trypanothione-glutathione thioltransferase from Trypanosoma cruzi. Murakami, Y.

The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Cell 16, — Nagajyothi, F. Mechanisms of Trypanosoma cruzi persistence in Chagas disease. Nagamune, K. Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei.


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GPI transamidase of Trypanosoma brucei has two previously uncharacterized trypanosomatid transamidase 1 and 2 and three common subunits. Oppenheimer, M. Biosynthesis of galactofuranose in kinetoplastids: novel therapeutic targets for treating leishmaniasis and chagas' disease. Enzyme Res. Pal, S.

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Ascorbate peroxidase from Leishmania major controls the virulence of infective stage of promastigotes by regulating oxidative stress. PloS ONE 5:e Patterson, S. Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.

Peng, D. Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei. Plewes, K. Iron superoxide dismutases targeted to the glycosomes of Leishmania chagasi are important for survival. Poole, L. The basics of thiols and cysteines in redox biology and chemistry. Romao, S. The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival. Roper, J. Cloning and characterisation of the UDP-glucose 4'-epimerase of Trypanosoma cruzi. The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number.

Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei. Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure. Scarim, C. Current advances in drug discovery for Chagas disease. Sies, H. Oxidative Stress.

Signorell, A. Perturbation of phosphatidylethanolamine synthesis affects mitochondrial morphology and cell-cycle progression in procyclic-form Trypanosoma brucei. Soares Medeiros, L. Sosa, E. Target-Pathogen: a structural bioinformatic approach to prioritize drug targets in pathogens. Sousa, A. Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum.


  1. Epidemiology of American trypanosomiasis (Chagas disease). - Abstract - Europe PMC.
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    Biochimie , — Sykes, M.

    'Kissing bug' disease more deadly than thought

    Tarleton, R. Chagas disease: a solvable problem, ignored. Trends Mol. Taylor, M. The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. Tovar, J. Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus. Turnock, D. Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi , and Leishmania major. Cell 6, — Turrens, J. Oxidative stress and antioxidant defenses: a target for the treatment of diseases caused by parasitic protozoa.

    Aspects Med. Tyler, K. The life cycle of Trypanosoma cruzi revisited. Urbina, J. Specific chemotherapy of Chagas disease: relevance, current limitations, and new approaches. Antiproliferative effects of delta 24 25 sterol methyl transferase inhibitors on Trypanosoma Schizotrypanum cruzi: in vitro and in vivo studies.

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    [Full text] Chagas disease: from Latin America to the world | RIP

    RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome. Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum. Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.

    Wyatt, P. Target validation: linking target and chemical properties to desired product profile. Wyllie, S. Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods. Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials.

    Xu, W. Sterol biosynthesis is required for heat resistance but not extracellular survival in Leishmania. Keywords: Trypanosoma cruzi , chagas disease, chemotherapautics, drug discovery, drug validation. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.

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